PENGARUH EKSTRAK KOMBINASI DAN MIKROEMULSIFIKASI TERHADAP AKTIVITAS HAMBATAN TIROSINASE DAN ANTIOKSIDAN DARI KULIT BATANG NANGKA (Artocarpus heterophyllus L.) DAN KULIT BUAH DELIMA (Punica granatum L.)
DOI:
https://doi.org/10.33578/mbi.v17i8.340Keywords:
mikroemulsifikasi, kulit batang nangka, tirosinaseAbstract
Penelitian ini bertujuan untuk mengevaluasi aktivitas penghambatan tirosinase dan antioksidan (AO) dari ekstrak kombinasi mikroemulsi (MCE) kulit batang nangka (Artocarpus heteropyllus L.) dan kulit buah delima (Punica granatum L.) memiliki efek mencerahkan kulit secara alami untuk meningkatkan depigmentasi dan menentukan mikroemulsi. Kombinasi ekstrak (MCE) dalam penghambatan tirosinase dan aktivitas antioksidan.
References
Sholikha M, Wulandari A. Phytochemical Screening And Tyrosinase Inhibition Activity Of Leaves Cassia siamea L. J Midpro [Internet]. 2020 Dec 1;12(2):198. Available from: http://jurnalkesehatan.unisla.ac.id/index.php/midpro/article/view/240
Mohiuddin AK. Skin Lightening & Management of Hyperpigmentation. 2019;2(2).
Ogbechie-Godec OA, Elbuluk N. Melasma: an Up-to-Date Comprehensive Review. Dermatol Ther (Heidelb). 2017;7(3):305–18.
Desmedt B, Courselle P, De Beer JO, Rogiers V, Grosber M, Deconinck E, et al. Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe. J Eur Acad Dermatology Venereol. 2016;30(6):943–50.
Couteau C, Coiffard L. Overview of skin whitening agents: Drugs and cosmetic products. Cosmetics. 2016;3(3).
Wang Y, Hao M-M, Sun Y, Wang L-F, Wang H, Zhang Y-J, et al. Synergistic Promotion on Tyrosinase Inhibition by Antioxidants. Molecules [Internet]. 2018 Jan 4;23(1):106. Available from: http://www.mdpi.com/1420-3049/23/1/106
Batubara I, Darusman LK, Mitsunaga T, Rahminiwati M, Djauhari E. Potency of Indonesian medicinal plants as tyrosinase inhibitor and antioxidant agent. Vol. 10, Journal of Biological Sciences. 2010. p. 138–44.
Prakash O, Kumar R, Mishra A, Gupta R . Artocarpus heterophyllus (Jackfruit)_ An overview Prakash O, Kumar R, Mishra A, Gupta R - Phcog Rev. 2009;(6):353–8.
Nguyen HX, Nguyen NT, Nguyen MHK, Le TH, Do TN, Hung TM, et al. Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous. Chem Cent J. 2016;10(1):4–9.
Arung ET, Shimizu K, Kondo R. Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis. Biol Pharm Bull. 2006;29(9):1966–9.
Yoshimura M, Watanabe YW, Kasai K, Amakoshi JY, Oga TK. Inhibitory Effect of an Ellagic Acid-Rich Pomegranate Extract on Tyrosinase Activity and Ultraviolet-Induced Pigmentation. 2005;69(12):2368–73.
Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem. 2000;48(10):4581–9.
Wang HM, Chen CY, Wen ZH. Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase. Exp Dermatol. 2011;20(3):242–8.
Sharma S-YS, Vinay K. Sharma, Niti. Mushroom Tyrosinase : Recent Prospects. J Agric Food Chem. 2003;(51):2837–53.
Zheng ZP, Cheng KW, To JTK, Li H, Wang M. Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent. Mol Nutr Food Res. 2008;52(12):1530–8.
Masum MN, Yamauchi K, Mitsunaga T. Tyrosinase inhibitors from natural and synthetic sources as skin-lightening agents. Vol. 7, Reviews in Agricultural Science. 2019.
Nurrochmad A, Wirasti W, Dirman A, Lukitaningsih E, Rahmawati A, Fakhrudin N. Effects of Antioxidant, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase of The Extract and Fraction From Turbinaria decurrens Bory. Indones J Pharm [Internet]. 2018 Dec 17;29(4):188. Available from: http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1422
Chang T. An Updated Review of Tyrosinase Inhibitors. 2009;(Figure 1):2440–75.
Azeem A, Rizwan M, Ahmad F, Iqbal Z, Khar R, Aqil M, et al. Emerging Role of Microemulsions in Cosmetics. Recent Pat Drug Deliv Formul. 2008 Feb 1;2:275–89.
Harborne, J.B 1996. Metode Fitokimia Penuntun Cara Modern Menganalisa Tumbuhan. (Kosasih Padmawinata). ITB. Bandung. Metode Fitokimia Penuntun Cara Modern Menganalisis Tumbuhan. 2nd ed. ITB; 1987.
Chang CC, Yang MH, Wen HM, Chern JC. Estimation of total flavonoid content in propolis by two complementary colometric methods. J Food Drug Anal. 2002;10(3):178–82.
cuniff p. official methods of analysis of AOAC international. 16th ed. USA; 1996.
Noor SU, Faridah, Magdalena P. Uji Aktivitas Inhibisi Enzim Tirosinase In-Vitro Krim Ekstrak Akar Manis (Glycyrrhiza glabra L.). J Ilmu Kefarmasian Indonesia. 2018;16(2):150–8.
Alamsyah N, Djamil R, Rahmat D. Antioxidant activity of combination banana peel (Musa paradisiaca) and watermelon rind (Citrullus vulgaris) extract in lotion dosage form. Asian J Pharm Clin Res. 2016;9:300–4.
Üstündağ Okur N, Çağlar EŞ, Pekcan AN, Okur ME, Ayla Ş. Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment. J Res Pharm. 2019;23(4):662–70.
Soyata A, Chaerunisaa AY. Whitening Agent: Mekanisme, Sumber dari Alam dan Teknologi Formulasinya. Maj Farmasetika.2021;6(2):169.doi:10.24198/mfarmasetika.v6i2.28139.
Wang Y, Hao M-M,Sun Y, et al. Synergistic Promotion on Tyrosinase inhibition by antioxidants. Molecules. 2018;23(1):106.doi:10.3390/molecules23010106
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